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2 edition of Modulation of apoptosis by HSP72 in human myeloid leukaemia and endothelial cells found in the catalog.

Modulation of apoptosis by HSP72 in human myeloid leukaemia and endothelial cells

Mark Lucas

Modulation of apoptosis by HSP72 in human myeloid leukaemia and endothelial cells

by Mark Lucas

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  • 21 Currently reading

Published by typescript in [s.l.] .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Warwick, 1999.

StatementMark Lucas.
The Physical Object
Paginationxx, 199, [45]p.
Number of Pages199
ID Numbers
Open LibraryOL20136774M

Modulation of these proteins may overcome the resistance and increase efficacy of anticancer therapies.\ud \ud In this study, resveratrol caused significant dose-dependent apoptosis or necrosis in the lymphoid and myeloid leukaemia cell .   CD99 is a kD transmembrane protein with a high-level surface expression on pediatric leukemias and Ewing tumor (ET) cells. 1, 2 On B lymphocytes, its level is determined by maturation Cited by:

Anaplasma phagocytophilum delays spontaneous human neutrophil apoptosis by modulation of multiple apoptotic pathways Article in Cellular Microbiology 8(9) October with 23 Reads. Metabolic homeostasis is a fundamental property of cells that becomes dysregulated in cancer to meet the altered, often heightened, demand for metabolism for increased growth and proliferation. Oncogenic mutations can directly change cellular metabolism in a cell-intrinsic manner, priming cells .

  Schwemmlein M, Peipp M, Barbin K, Saul D, Stockmeyer B, Repp R, Birkmann J, Oduncu F, Emmerich B, Fey GH () A CDspecific single-chain immunotoxin mediates potent apoptosis of cultured human myeloid leukaemia cells Author: Edwin Bremer, Wijnand Helfrich. Background. Human cytomegalovirus (hCMV) is involved in the pathogenesis of atherosclerosis. We have previously shown in patients with atherosclerosis that antibodies directed against the hCMV-derived proteins US28 and UL are able to induce endothelial cell damage and apoptosis of non-stressed endothelial cells Cited by:


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Modulation of apoptosis by HSP72 in human myeloid leukaemia and endothelial cells by Mark Lucas Download PDF EPUB FB2

Modulation of apoptosis by HSP72 in human myeloid leukaemia and endothelial cells. (Thesis) Lucas M. Publisher: University of Warwick [] Metadata Source: The British Author: Lucas M.

Modulation of apoptosis by HSP72 in human myeloid leukaemia and endothelial cells. Author: Lucas, Mark. Awarding Body: University of Warwick Current Institution: University of Warwick Date of. Some bioeffects induced on sonicated HL cells, such as inhibition of cell proliferation, DNA repair, and cell-dependent apoptosis, were found to be similar to those produced byγ -irradiation.

Cited by:   In contrast, the rate of apoptosis was comparable in T and B cells from +/+ or −/− mice, suggesting a specific role for ICSBP in apoptosis in the myeloid lineage. Analysis of apoptosis induced by etoposide confirmed the specific proapoptotic role of ICSBP in myeloid by: high power and low frequency may induce time-dependent apoptosis in cultured myeloid leukemic cells.

MATERIALS AND METHODS Leukemia Cell Line Cultures All cultures of human leukemic cells. Request PDF | HSP27 protects AML cells against VPinduced apoptosis through modulation of p38 and c-Jun | To investigate 1) the signal transduction pathways affected by heat shock protein   Hsp90 has also been implicated in the induction of apoptosis; Galea-Lauri et al 16 demonstrated hsp90 overexpressing transformed haemopoietic cells to have increased apoptosis Cited by: At this level, protecting endothelial cells or their precursors is a need.

As previously described, SSc pathologic process targets not only endothelial cells from microvessels but also the mechanism to repair the vascular damage. Endothelial cell apoptosis is induced by pathologic serum exposition Cited by: 5.

Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis.

Fredly H(1), Ersvær E, Gjertsen BT, Bruserud O. Author information: (1)Section for Hematology Cited by:   In human chronic myeloid leukaemia (CML) cells, HSP70 can mediate Bcr-Abl-induced resistance to TNFα-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by preventing the.

KSHV infects endothelial cells or circulating endothelial and/or hematopoietic progenitors. Its oncogenicity is supported by the numerous pro-angiogenic molecules that are induced following the infection of endothelial cells, including the VEGF-VEGFR family, cyclooxygenase 2 (COX2) and angiogenin.

However, in the general population, KSHV infection rarely leads to KS, indicating the need of cofactors, such as immunosuppression, in order for a tumor Cited by: AA induces apoptosis in HL cells.

Annexin V-FITC/PI double staining and flow cytometric analysis were utilized to assess the apoptotic rate of HL cells treated with AA, as shown in Fig. early apoptotic rates of HL cells. Bendall LJ et al () Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of β-1 integrins and β-1 integrin mechanisms.

Blood – PubMed Google Scholar Boekhorst PA et al () Multidrug resistant cells with high proliferative capacity determine response to therapy in acute myeloid : A.

List. Cells lacking hsp and hsp, the two genes that code for inductive HSP70, are very sensitive to apoptosis induced by a wide range of lethal stimuli. 39 Further, the testis specific isoform of HSP70. Little is known about the potentially chemopreventive mechanisms of anthocyanins apart from their antioxidant activity.

We investigated the in vitro capacity of the anthocyanin cyanidinO-β-glucopyranoside (Cy-g) to induce apoptosis in T-lymphoblastoid, as well as apoptosis and differentiation in HL promyelocytic gh Cy-g-induced apoptosis.

Ectopic expression of the NPM-MLF1 fusion protein induced apoptosis in human erythroleukemia cell lines such as K and HEL cells, but the fact that it failed to do so in IL-3 Cited by: New Molecular Therapy Targets in Acute Myeloid Leukemia.

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells. () Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.

Leukemia Cited by: 9. The level of Hsp72 expression in PC12 cells used in this study was within the normal physiological range, because ectopic Hsp72 expression is comparable to the level of Hsp72 induced during.

Increased cAMP levels have been shown to induce apoptosis in B cells, as well as T cells Microinjection of cAMP into the myeloid leukemia cell line, IPC, induces apoptosis Cited by: Abstract. Hsp72 protects cells against apoptosis in response to various stresses.

By simultaneously measuring cytochrome c localization and nuclear morphology in mouse embryo fibroblasts, we have shown that Hsp72. Abstract. The human body is composed of approximately 10 14 cells, each of which is capable of committing suicide by apoptosis. Normally, the processes of cell division and cell death are tightly .The molecular functions of Hsp70 in cancer cells are far from being understood but one aspect relies on interaction with multiple partners in the signaling pathways of apoptosis and senescence.

Hsp has been found to interact with the mammalian MAPKKK apoptosis signal-regulated kinase 1 (Ask-1), JNK and p38MAPK leading to blockage of stress-induced cell death .Guo F, Sigua C, Bali P et al () Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.

Blood – PubMed CrossRef .